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human hepatocellular carcinoma cell lines heparg  (ATCC)


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    ATCC human hepatocellular carcinoma cell lines heparg
    Human Hepatocellular Carcinoma Cell Lines Heparg, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 3826 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+hepatocellular+carcinoma+cell+lines+heparg/Hep+G2%3B+Hepatocellular%3B+Carcinoma%3B+Human/pm37121360-58-0-7
    Average 99 stars, based on 3826 article reviews
    human hepatocellular carcinoma cell lines heparg - by Bioz Stars, 2026-10
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    Cell Culture:

    Article Title: Blocking Autophagy by the Two-Pore Channels Antagonist Tetrandrine Improves Sorafenib-Induced Death of Hepatocellular Carcinoma Cells.
    Article Snippet: Sorafenib, an oral multi-kinase inhibitor, used to treat hepatocellular carcinoma (HCC).. However, drug resistance is still common in several HCC patients.. This complex mechanism is not yet fully elucidated, driving the search for new therapeutic targets to potentiate the antitumoral effect of sorafenib.

    Modification:

    Article Title: Blocking Autophagy by the Two-Pore Channels Antagonist Tetrandrine Improves Sorafenib-Induced Death of Hepatocellular Carcinoma Cells.
    Article Snippet: Sorafenib, an oral multi-kinase inhibitor, used to treat hepatocellular carcinoma (HCC).. However, drug resistance is still common in several HCC patients.. This complex mechanism is not yet fully elucidated, driving the search for new therapeutic targets to potentiate the antitumoral effect of sorafenib.



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    Fisetin (FST) attenuates acetaminophen (APAP)-induced cytotoxicity by promoting autophagy and inhibiting inflammasome activation in L-02 cells. (A, B) Cell viability was assessed by MTT assay in response to APAP (10 mM) or N-acetyl-p-benzoquinoneimine (NAPQI) (200 μM) exposure for different periods in L-02 cells. (C, D) Cell viability was assessed by MTT assay in response to APAP (10 mM) or NAPQI (200 μM) exposure for 48 h in <t>HepaRG</t> cells. (E) Cell viability was assessed by MTT assay for different concentration of FST in L-02 cells. (F) Messenger RNA (mRNA) expression of ATG genes was determined by RT-PCR in the presence of APAP (10 mM) for 48 h. (G) Western blot of autophagy-related proteins in L-02 cells supplemented with APAP (10 mM) for 48 h. (H) Quantification of Western blot. (I, J) Representative immunofluorescence images of mRFP-GFP-LC3 in L-02 cells supplemented with APAP (10 mM) for 48 h. Representative profiles of autophagosomes (RFP+GFP+dots) and autolysosomes (RFP+GFP-dots) per cell section, assessed by confocal microscopy are shown and were quantified. (K, L) Autophagic vacuoles (autophagosomes) were assessed by transmission electron microscopy (TEM) plus APAP (10 mM) for 48 h in L-02 cells. Representative TEM images are shown and typical autophagosomes are marked with black arrows. Autophagosome numbers per cell were calculated by counting the number of double-membrane organelles in 10 cells. Data are expressed as mean ± SEM (n = 3). **P < 0.01, ***P < 0.001 compared to control; # < 0.05, ### < 0.001 compared to APAP.
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    Fisetin (FST) attenuates acetaminophen (APAP)-induced cytotoxicity by promoting autophagy and inhibiting inflammasome activation in L-02 cells. (A, B) Cell viability was assessed by MTT assay in response to APAP (10 mM) or N-acetyl-p-benzoquinoneimine (NAPQI) (200 μM) exposure for different periods in L-02 cells. (C, D) Cell viability was assessed by MTT assay in response to APAP (10 mM) or NAPQI (200 μM) exposure for 48 h in HepaRG cells. (E) Cell viability was assessed by MTT assay for different concentration of FST in L-02 cells. (F) Messenger RNA (mRNA) expression of ATG genes was determined by RT-PCR in the presence of APAP (10 mM) for 48 h. (G) Western blot of autophagy-related proteins in L-02 cells supplemented with APAP (10 mM) for 48 h. (H) Quantification of Western blot. (I, J) Representative immunofluorescence images of mRFP-GFP-LC3 in L-02 cells supplemented with APAP (10 mM) for 48 h. Representative profiles of autophagosomes (RFP+GFP+dots) and autolysosomes (RFP+GFP-dots) per cell section, assessed by confocal microscopy are shown and were quantified. (K, L) Autophagic vacuoles (autophagosomes) were assessed by transmission electron microscopy (TEM) plus APAP (10 mM) for 48 h in L-02 cells. Representative TEM images are shown and typical autophagosomes are marked with black arrows. Autophagosome numbers per cell were calculated by counting the number of double-membrane organelles in 10 cells. Data are expressed as mean ± SEM (n = 3). **P < 0.01, ***P < 0.001 compared to control; # < 0.05, ### < 0.001 compared to APAP.

    Journal: Frontiers in Pharmacology

    Article Title: Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy

    doi: 10.3389/fphar.2020.00162

    Figure Lengend Snippet: Fisetin (FST) attenuates acetaminophen (APAP)-induced cytotoxicity by promoting autophagy and inhibiting inflammasome activation in L-02 cells. (A, B) Cell viability was assessed by MTT assay in response to APAP (10 mM) or N-acetyl-p-benzoquinoneimine (NAPQI) (200 μM) exposure for different periods in L-02 cells. (C, D) Cell viability was assessed by MTT assay in response to APAP (10 mM) or NAPQI (200 μM) exposure for 48 h in HepaRG cells. (E) Cell viability was assessed by MTT assay for different concentration of FST in L-02 cells. (F) Messenger RNA (mRNA) expression of ATG genes was determined by RT-PCR in the presence of APAP (10 mM) for 48 h. (G) Western blot of autophagy-related proteins in L-02 cells supplemented with APAP (10 mM) for 48 h. (H) Quantification of Western blot. (I, J) Representative immunofluorescence images of mRFP-GFP-LC3 in L-02 cells supplemented with APAP (10 mM) for 48 h. Representative profiles of autophagosomes (RFP+GFP+dots) and autolysosomes (RFP+GFP-dots) per cell section, assessed by confocal microscopy are shown and were quantified. (K, L) Autophagic vacuoles (autophagosomes) were assessed by transmission electron microscopy (TEM) plus APAP (10 mM) for 48 h in L-02 cells. Representative TEM images are shown and typical autophagosomes are marked with black arrows. Autophagosome numbers per cell were calculated by counting the number of double-membrane organelles in 10 cells. Data are expressed as mean ± SEM (n = 3). **P < 0.01, ***P < 0.001 compared to control; # < 0.05, ### < 0.001 compared to APAP.

    Article Snippet: The human hepatocellular carcinoma cell line HepaRG ( ) was purchased from Merck Millipore (Burlington, MA, USA).

    Techniques: Activation Assay, MTT Assay, Concentration Assay, Expressing, Reverse Transcription Polymerase Chain Reaction, Western Blot, Immunofluorescence, Confocal Microscopy, Transmission Assay, Electron Microscopy, Membrane, Control